We've known for some time that pomegranate juice extract helps slow the progression of prostate cancer, not only in the lab but in humans as well. Now researchers at the University of California, Riverside, have identified the components of pomegranate juice that provide the beneficial effect. Their discovery could lead to better treatment of prostate cancer by modifying the active components to make them even more effective. In addition, the investigators learned that pomegranate juice inhibits the function of a bone-marrow protein that induces cancer cells to metastasize to bone, where they can then form new tumors. Because the proteins and genes involved in the movement of prostate cancer cells are pretty much the same as those involved in the movement of other kinds of cancer cells, the modifications of pomegranate juice envisioned could possibly work in other types of cancer treatment. The study was presented on December 12 at the annual meeting of the American Society for Cell Biology.